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Midazolam - Fentanyl Sedation


DILUTION PROTOCOL for mida-fentanyl may vary from other health institution.


Preparation for each dosage form:
1. Inj Midazolam: 5mg/1ml and 15mg/3ml
2. Inj Fentanyl: 100mcg/2ml

Dilution:
||||||| 30MG MIDAZOLAM |||||| + |||||| 300MCG FENTANYL ||||||
dilute in 
30ML NORMAL SALINE
in 50ML syringe

For every 1ml/hr, 
1mg/hr midazolam + 10mcg/ml fentanyl 
is administered.

Infusion starting dose : 3 ml/hr
Titrate to the desired effect
Bolus dose may be required for faster effect ( 3 - 5 mls), followed by infusion dose.

Source: ETD HSAJB

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Midazolam - Morphine Dilution

Mida-Morphine for sedation may vary from other healthcare institution. Preparation available in KKM: 1) Midazolam injection: 5mg/ml, 15mg/3ml 2) Morphine Injection: 10mg/ml Dilute: ||| Midazolam 30mg (6ml) ||| + ||| Morphine 30mg (3ml) ||| in 21ml Normal Saline (qs. 30ml) in 50cc syringe ~ ~ ~ Midoazolam 1mg/ml and Morphine 1mg/ml   1. May give loading dose of 0.05 mg/kg midazolam 2. Start at 0.06 mcg/kg/hr of midazolam 3. Dose range: 0.06 - 2 mg/kg/hr 4. May increase by 1ml/hr every 20 minutes till target RASS -2 to +1 achieved     Source: Medication Reconstitution & Medication Dilution Reference 2013 HSAJB